O uso prolongado do deflazacorte em camundongos com distrofia muscular reduz a fibrose do músculo cardíaco

Brasil - camundongos com distrofia muscular e 6 meses de vida foram tratados por 15 meses com deflazacorte. Os animais tratados apresentaram redução da fibrose do músculo cardíaco demonstrando os benefícios a longo prazo do tratamento com cortióides.

O resumo em inglês pode ser lido abaixo:

(Muscle & Nerve. 40 (3) 466-68,2009) Long-term therapy with deflazacort decreases myocardial fibrosis in mdx mice

Maria Julia Marques, Daniella Silva Oggiam, Isabel Cristina Chagas Barbin, Renato Ferretti, Humberto Santo Neto - Brazil

We evaluated the effects of long-term administration of deflazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF. We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart.

Fonte: http://distrofiamuscular.net/noticias.htm