Expressão das integrinas nos linfócitos T de pacientes com distrofia muscular de Duchenne

Rio de Janeiro e França - receptores VLA-4 e VLA-5 e VLA-6 foram estudados nos línfócitos T de pacientes com Duchenne; os receptores de integrinas VLA-4 e VLA-5 estavam significantemente aumentados nos linfócitos T; estas integrinas podem contribuir para direcionar estas células para os músculos e agravar o dano e a fibrose dos músculos.

O resumo em inglês pode ser lido abaixo:

(Journal of Neuroimmunology, 2010) Differential integrin expression by T lymphocytes: Potential role in DMD muscle damage

Fernanda Pinto-Mariz, Luciana Rodrigues Carvalho, Wallace de Mello, Alexandra de Queiroz Campos Araújo, Márcia Gonçalves Ribeiro, Maria do Carmo Soares Alves Cunha, Thomas Voit, Gillian Butler-Browne, Suse Dayse Silva-Barbosa, Wilson Savino - Brazil and France

The expression and function of integrin-type extracellular matrix receptors, VLA-4 and VLA-5, and laminin receptor VLA-6 on the surface of CD3+CD4+ and CD3+CD8+ defined T cell populations was evaluated in the blood of Duchenne muscular dystrophy (DMD) patients and healthy individuals. Both the number of CD4+ and CD8+ T cell subsets expressing VLA-4 or VLA-5 and the fibronectin-driven T cell migration was significantly higher in DMD patients. These data indicate that interactions of VLA-4 and/or VLA-5 with fibronectin may drive T lymphocytes to specific niches within muscle, contributing to tissue damage and fibrosis in DMD patients.

Fonte: http://distrofiamuscular.net/noticias.htm