Resumos apresentados na Conferência de Pesquisa em Doenças Neuromusculares na Inglaterra
Inglaterra - nesta conferência realizada em março foram apresentadas as mais recentes pesquisas em distrofia muscular com ênfase nos estudos com oligonucleotídeos, estudos experimentais e ensaios clínicos, a maioria já apresentada em outros congressos.
Os resumos foram publicados em um suplemento da Revista Neuromuscular Disorders e podem ser lidos abaixo:
(Abstracts of the UK Neuromuscular Translational Research Conference Oxford, UK 25-26 March 2010)
Results of a systemic antisense study in Duchenne muscular dystrophy
Current progress with the systemic administration trial of AVI-4658, a novel Phosphorodiamidate Morpholino Oligomer
(PMO) skipping dystrophin exon 51 in Duchenne muscular dystrophy (DMD)
Multiexon skipping in Duchenne muscular dystrophy
Lentivirus-mediated stem cell therapy for Duchenne muscular dystrophy
Induction of dystrophin in Duchenne muscular dystrophy patients by antisense oligonucleotide AVI-4658 restores the dystrophin-associated glycoprotein complex
Evaluation of the truncated products of exon and multiple exon skipping in DMD therapy
Translation related clinical trials in duchenne muscular dystrophy (DMD) in the UK
Exploring emotional impact in a proof-of-principle single-blind, controlled, two-doses escalation intramuscular study of a morpholino splice-switching oligonucleotide (AVI-4658) trial to induce dystrophin restoration in children with Duchenne muscular dystrophy
A Novel Ankle foot orthoses/footwear combination to aid walking in Duchenne muscular dystrophy
Parental stress levels in parents of children with muscular dystrophy
UK NorthStar Neuromuscular Clinical Network (NSCN): National audit results in Duchenne muscular dystrophy (DMD) corticosteroid practice, vitamin D status and bone health
An audit of bone density and vertebral fractures during steroid treatment in Duchenne muscular dystrophy
Blocking calcium influx with streptomycin worsens myocardial pathology in the mdx mouse model of muscular dystrophy
Utrophin luciferase knock-in mouse model for in vivo assessment of drug efficacy in preclinical trials for utrophin upregulation
Rescue of severely affected dystrophin/utrophin deficient mice by morpholino-oligomer mediated exon skipping
Chronic long term administration of phosphorodiamidate morpholino oligomer profoundly ameliorates activity, muscle strength and phenotype in dystrophic mdx mice
Preventing dystroglycan phosphorylation as a route to therapy in DMD
Fonte: http://distrofiamuscular.net/noticias.htm |
