Melatonina reverte o estado hiperoxidativo dos glóbulos vermelhos na distrofia muscular de Duchenne

Espanha - em complemento a pesquisa divulgada em 2010 que demonstrou que a melatonina em doses elevadas pode ser útil na distrofia muscular de Duchenne a mesma população foi estudada com relação ao stress oxidativo. A pesquisa foi feita com os globulos vermelhos destes pacientes. Os resultados demonstraram uma redução do stress oxidativo aos valores normais após um tratamento de 9 meses com a melatonina.

O resumo em inglês pode ser lido abaixo:

(Clinical Biochemistry, 2011) Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy

Mariam Chahbouni, Germaine Escames, Luis C. López, Belén Sevilla, Carolina Doerrier, Antonio Muñoz-Hoyos, Antonio Molina-Carballo and Darío Acuña-Castroviejo - Spain

Abstract:

Objectives: To analyzed whether the antioxidant melatonin could reduce the hyperoxidative status in the blood of patients with Duchenne's muscular dystrophy.

Design and methods: Ten patients aged 12.8 ± 0.9 years were treated with melatonin (60 mg at 21:00 h plus 10 mg at 09:00 h) for 9 months, and erythrocyte markers of oxidative stress were determined at 3, 6, and 9 months of treatment. Healthy age- and sex-matched subjects served as controls.
Results: Prior to treatment, the patients had higher glutathione disulfide/glutathione ratio and higher glutathione transferase and superoxide dismutase activities, and lower glutathione reductase activity than controls. After 3 months of melatonin treatment, the hyperoxidative status of these patients was counteracted, being reduced to the normal redox state between 3 and 9 months.
Conclusion: These results, together with the reduction in the inflammatory process and in muscle injury recently reported in the same patients, support the efficacy of melatonin therapy in DMD patients.

Fonte: http://distrofiamuscular.net/noticias.htm